In regards to your doctor's office, pharmacy prescription reminders, school closings, weather advisories, local municipalities, reverse 911, emergency calls, etc:
No. The only numbers that are blocked are reported, illegal robocallers.
These 'good' kinds of robocalls should get through to you as normal.
If you experience issues receiving a legitimate call, please report it using the 'Report A Number' feature in your Nomorobo account.